Article

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

2020-11-19

Abstract excerpt

<h4>Objective</h4> Polymorphic variation of immune system proteins can drive variability of individual immune responses. ER aminopeptidase 1 (ERAP1) generates antigenic peptides for presentation by MHC class I molecules. Coding single nucleotide polymorphisms (SNPs) in ERAP1 have been associated with predisposition to inflammatory rheumatic disease and shown to affect functional properties of the enzyme, but the...

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Literature Corpus work: 01c5af82-0e05-51dd-96c9-af5bf0d25ece
DOI: 10.1101/2020.11.19.389403

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