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Article

A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2012

Evnouchidou Irini, Birtley James, Seregin Sergey, Papakyriakou Athanasios, Zervoudi Efthalia, Samiotaki Martina, Panayotou George, Giastas Petros, Petrakis Olivia, Georgiadis Dimitris, Amalfitano Andrea, Saridakis Emmanuel, Mavridis Irene M, Stratikos Efstratios

Abstract excerpt

Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) cooperate to trim antigenic peptide precursors for loading onto MHC class I molecules and help regulate the adaptive immune response. Common coding single nucleotide polymorphisms in ERAP1 and ERAP2 have been linked with predisposition to human diseases ranging from viral and bacterial infections to autoimmunity and cancer. It has been hypothesized...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22837489
DOI: 10.4049/jimmunol.1200918
PMCID: PMC3530405

Genes

ERAP2
ERAP1

Variants

rs2549782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.PMID 22837489Read ↗

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