Article
Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection.
Human molecular genetics - 1 Dec 2010
Cagliani Rachele, Riva Stefania, Biasin Mara, Fumagalli Matteo, Pozzoli Uberto, Lo Caputo Sergio, Mazzotta Francesco, Piacentini Luca, Bresolin Nereo, Clerici Mario, Sironi Manuela
Abstract excerpt
Human ERAP1 and ERAP2 encode two endoplasmic reticulum aminopeptidases. These enzymes trim peptides to optimal size for loading onto major histocompatibility complex class I molecules and shape the antigenic repertoire presented to CD8(+) T cells. Therefore, ERAP1 and ERAP2 may be considered potential selection targets and modulators of infection susceptibility. We resequenced two genic regions in ERAP1 and ERAP2...
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