Article
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.
PLoS genetics - 14 Oct 2010
Andrés Aida M, Dennis Megan Y, Kretzschmar Warren W, Cannons Jennifer L, Lee-Lin Shih-Queen, Hurle Belen, Schwartzberg Pamela L, Williamson Scott H, Bustamante Carlos D, Nielsen Rasmus, Clark Andrew G, Green Eric D
Abstract excerpt
A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC complex remains one of the best-known examples of natural selection in humans, with well-established genetic signatures and biological mechanisms for the action of selection. Here, we present genetic and functional evidence that another gene...
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