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How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

30 Oct 2018

Abstract excerpt

06:02). The endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 are also risk factors for these diseases. Since both enzymes are involved in the final processing steps of MHC-I ligands it is reasonable to assume that MHC-I-bound peptides play a significant pathogenetic role. This review will mainly focus on recent studies concerning the effects of ERAP1 and ERAP2 polymorphism and expression on shaping the...

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PMID: 30425713
DOI: 10.3389/fimmu.2018.02463

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