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Article

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.

Scientific reports - 10 Jul 2018

Paladini Fabiana, Fiorillo Maria Teresa, Vitulano Carolina, Tedeschi Valentina, Piga Matteo, Cauli Alberto, Mathieu Alessandro, Sorrentino Rosa

Abstract excerpt

The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune and non-immune functions. Most studies however have focused on their role in shaping the HLA class I peptidome by trimming peptides to the optimal size. Genome Wide Association Studies highlighted non-synonymous polymorphisms in their coding regions as associated with several immune mediated diseases. The two genes...

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Topics

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Share to Aminopeptidases
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 5

Share to DNA, Intergenic

Share to Endoplasmic Reticulum

Share to Gene Expression Regulation

Share to Minor Histocompatibility Antigens

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 29991817
DOI: 10.1038/s41598-018-28799-8
PMCID: PMC6039459

Genes

ERAP2
ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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