Article

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

2020-11-10

Abstract excerpt

Tau is a microtubule-associated protein that regulates the stability of microtubules. The affinity of tau for microtubules is modulated by post-translational modifications, and the dysregulation of these events has been associated with the aberrant aggregation of tau in Alzheimer's disease and related tauopathies. Here, we use the metainference cryo-electron microscopy approach to determine an ensemble of structur...

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Literature Corpus work: 39834fd8-8f5a-53ba-a9cd-2bcedf197030
DOI: 10.1101/2020.11.10.376285

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