Article

Ensemble-based design of tau to inhibit aggregation while preserving biological activity

2024-01-16

Abstract excerpt

<title>Abstract</title> <p>The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. The structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-discipl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65200edc-096d-5aeb-9109-be2745f83221
DOI: 10.21203/rs.3.rs-3796916/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ensemble-based design of tau to inhibit aggregation while preserving biological activityDOI 10.21203/rs.3.rs-3796916/v1Read

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence contextSemantic proximity Read

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context.Semantic proximity Read

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregationSemantic proximity Read

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregationSemantic proximity Read

Revealing the conformational landscape of tau P → L mutants in R23 tau macromolecule: A pathway to targeted therapeutic design.Semantic proximity Read

FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation.Semantic proximity Read

Precision Proteoform Design for 4R Tau Isoform Selective Templated AggregationSemantic proximity Read

Tau local structure shields amyloid motif and controls aggregation propensitySemantic proximity Read

Tau local structure shields an amyloid-forming motif and controls aggregation propensitySemantic proximity Read

In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics.Semantic proximity Read

[Tauopathies : From molecule to therapy].Semantic proximity Read

<i>In vitro</i> tau aggregation inducer molecules influence the effects of <i>MAPT</i> mutations on aggregation dynamicsSemantic proximity Read