Article

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological context

2016-02-29

Abstract excerpt

<h4>ABSTRACT</h4> Impaired interactions of Tau protein with microtubules (MT) and Tau misfolding play a key role in Alzheimer disease (AD) and other neurodegenerative diseases collectively named Tauopathies. However, little is known about the molecular conformational changes that underlie Tau misfolding and aggregation in pathological conditions, due to the difficulty of studying structural aspects of this intrin...

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Literature Corpus work: 126b358d-6e44-53d7-a523-bcee1736dc20
DOI: 10.1101/041756

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