Article

Disease associated mutations in tau encode for changes in aggregate structure conformation

2023-04-24

Abstract excerpt

The accumulation of tau aggregates is associated with neurodegenerative diseases collectively known as tauopathies. Tau aggregates isolated from different tauopathies such as Alzheimer’s disease, corticobasal degeneration and progressive supranuclear palsy have distinct cryo-electron microscopy structures with respect to their packed fibril cores. To understand the mechanisms by which tau can be sensitized to form...

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Literature Corpus work: 6f443a76-945f-5396-9860-e4aefdec62d5
DOI: 10.1101/2023.04.24.537889

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