Article

Structural Insights into the Role of the Proline Rich Region in Tau Function

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Tau is a microtubule-associated protein that plays an important role in modulating axonal microtubules in neurons. Intracellular tau aggregates are found in a broad class of disorders, including Alzheimer’s disease, termed tauopathies. Tau is an intrinsically disordered protein, and its structural disorder appears to be critical to its microtubule-related functions. Tubulin binding sites are fou...

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Literature Corpus work: 64b55752-c8a8-59c2-907f-32bd90528cda
DOI: 10.1101/2024.09.20.614010

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