Article

Structures of AT8 and PHF1 Phospho-Mimetic Tau: Insights Into the Posttranslational Modification Code of Tau Amyloid Formation

2023-09-06

Abstract excerpt

The microtubule-associated protein tau aggregates into amyloid fibrils in Alzheimer’s disease and other neurodegenerative diseases. In these tauopathies, tau is hyperphosphorylated, suggesting that this posttranslational modification may induce pathological tau aggregation. Tau is also phosphorylated in normal developing brains. To investigate how tau phosphorylation induces amyloid fibrils, here we report the ato...

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Literature Corpus work: 90bee6c4-f7e3-5eff-ada7-9688462de999
DOI: 10.1101/2023.09.04.556256

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