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Article

Structural insights into the role of the proline rich region in tau function.

Structure (London, England : 1993) - 6 Mar 2025

Acosta Karen, Brue Christopher R, Holubovska Polina, Kim Hee Jong, Mayne Leland, Murakami Kenji, Rhoades Elizabeth

Abstract excerpt

Tau plays an important role in modulating axonal microtubules in neurons, while intracellular tau aggregates are found in many neurodegenerative disorders. Tubulin binding sites are found in tau's proline-rich region (PRR), microtubule binding repeats (MTBRs), and pseudo-repeat (R'). Tau phosphorylation sites, which cluster with high frequency within the PRR, regulate tubulin interactions and correlates with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39826549
DOI: 10.1016/j.str.2024.12.017
PMCID: PMC11890945

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