Article

The <i>in situ</i> structure of Parkinson’s disease-linked LRRK2

2019-11-10

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial Parkinson’s disease. LRRK2 is a multi-domain protein containing a kinase and GTPase. Using in situ cryo-electron tomography and subtomogram averaging, we reveal a 14-Å structure of LRRK2 bearing a pathogenic mutation that oligomerizes as a right-handed double-helix around microtubules, which are left-handed. Using integrativ...

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Literature Corpus work: 7be5dae3-5e40-574c-9985-d045ad81373e
DOI: 10.1101/837203

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