Article

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

2023-12-14

Abstract excerpt

The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. However, the structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-disciplinary approach, inc...

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Literature Corpus work: ea45d6f8-27e3-5ffa-b9ba-5962b517c42a
DOI: 10.1101/2023.12.13.571598

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