Article

Atomic model of microtubule-bound tau

2018-02-16

Abstract excerpt

Tau is a developmentally regulated protein found in axons, whose physiological role is to stabilize and bundle microtubules (MTs). Hyper-phosphorylation of tau is thought to cause its detachment from MTs and subsequent aggregation into pathological fibrils that have been implicated in Alzheimer’s disease pathogenesis. Despite its known MT binding role, there is no consensus regarding which tau residues are crucial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2635f49-3a80-5ca1-8d84-669b80cfb034
DOI: 10.1101/267153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atomic model of microtubule-bound tauDOI 10.1101/267153Read

Structural Insights into the Role of the Proline Rich Region in Tau FunctionSemantic proximity Read

Structural insights into the role of the proline rich region in tau function.Semantic proximity Read

Tau: More than a microtubule‐binding protein in neuronsSemantic proximity Read

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation MechanismsSemantic proximity Read

Tau filaments in neurodegenerative diseasesSemantic proximity Read

MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments.Semantic proximity Read

Structures of AT8 and PHF1 Phospho-Mimetic Tau: Insights Into the Posttranslational Modification Code of Tau Amyloid FormationSemantic proximity Read

Tau and neurodegeneration.Semantic proximity Read

The Pathogenic R5L Mutation Disrupts Formation of Tau Complexes on the Microtubule by Altering Local N-Terminal StructureSemantic proximity Read

The physiology and pathology of microtubule-associated protein tauSemantic proximity Read

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.Semantic proximity Read

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextSemantic proximity Read