Article

Tau amyloidogenesis begins with a loss of its conformational polymorphism

2020-06-20

Abstract excerpt

Knowledge on the molecular bases of early amyloid assembly is fundamental to understand its structure-dysfunction relationship during disease progression. Tauopathies, a well-defined set of neurodegenerative disorders that includes Alzheimer’s disease, are characterized by the pathological amyloid aggregation of tau. However, the underlying molecular mechanisms that trigger tau aggregation and toxicity are poorly...

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Literature Corpus work: 8a599974-6c0e-5e0e-a59c-b0ac72055af7
DOI: 10.1101/2020.06.18.158923

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