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Article

FMNL formins boost lamellipodial force generation.

Nature communications - 22 Mar 2017

Kage Frieda, Winterhoff Moritz, Dimchev Vanessa, Mueller Jan, Thalheim Tobias, Freise Anika, Brühmann Stefan, Kollasser Jana, Block Jennifer, Dimchev Georgi, Geyer Matthias, Schnittler Hans-Joachim, Brakebusch Cord, Stradal Theresia E B, Carlier Marie-France, Sixt Michael, Käs Josef, Faix Jan, Rottner Klemens

Abstract excerpt

Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleate and elongate actin filaments with complementary activities in vitro. In migrating B16-F1 melanoma cells, both...

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Source

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Identifiers

PMID: 28327544
DOI: 10.1038/ncomms14832
PMCID: PMC5364437

Genes

FMNL2
FMNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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