Article

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>For over three decades, we have known that oncogenic RAS alters the actin cytoskeleton organization and cell surface morphology. RAS activates the GTPase RAC1, which triggers the growth of branched actin networks to promote cell membrane protrusions. In melanoma, the hyperactive RAC1 mutant, Rac1P29S, was recently shown to drive extended lamellipodia, which then empower cell proliferati...

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Literature Corpus work: d7d79af4-66ce-5b24-8dbb-2a0818421b96
DOI: 10.21203/rs.3.rs-9293424/v1

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