Article

Basal extrusion drives cell invasion and mechanical stripping of E-cadherin

2018-11-06

Abstract excerpt

Metastasis is the predominant reason that patients succumb to cancer, yet the mechanisms that drive initial tumor cell invasion are poorly understood. We previously discovered that crowding-induced apical extrusion drives most epithelial cell death, critical to maintaining constant cell densities. Oncogenic mutations can disrupt apical cell extrusion, instead causing masses to form and aberrant basal extrusion. Us...

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Identifiers and source

Literature Corpus work: 08e7f2e9-084b-5df6-baf9-c70c997ed473
DOI: 10.1101/463646

Open publication

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