Article

Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions

2026-04-13

Abstract excerpt

For over three decades, we have known that oncogenic RAS alters the actin cytoskeleton organization and cell surface morphology 1,2 . RAS activates the GTPase RAC1, which triggers the growth of branched actin networks to promote cell membrane protrusions 3,4 . In melanoma, the hyperactive RAC1 mutant, Rac1 P29S , was recently shown to drive extended lamellipodia, which then empower cell proliferation through se...

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Literature Corpus work: 80dbd697-fbca-56ee-accd-452f108db659
DOI: 10.64898/2026.04.09.717047

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