Article
Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.
Nature communications - 11 Jan 2022
Pothapragada Shilpa P, Gupta Praver, Mukherjee Soumi, Das Tamal
Abstract excerpt
In epithelia, normal cells recognize and extrude out newly emerged transformed cells by competition. This process is the most fundamental epithelial defence against cancer, whose occasional failure promotes oncogenesis. However, little is known about what factors determine the success or failure of this defence. Here we report that mechanical stiffening of extracellular matrix attenuates the epithelial defence...
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