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Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

31 May 2019

Abstract excerpt

Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression by facilitating cell movement through physically constraining environments. To identify properties that enabled passage through physical constraints, cells that were more efficient at moving through narrow membrane micropores were selected from established...

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PMID: 31152052
DOI: 10.1242/jcs.224071

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