Article
Single-cell analysis based dissection of clonality in myelofibrosis.
Nature communications - 7 Jan 2020
Mylonas Elena, Yoshida Kenichi, Frick Mareike, Hoyer Kaja, Christen Friederike, Kaeda Jaspal, Obenaus Matthias, Noerenberg Daniel, Hennch Cornelius, Chan Willy, Ochi Yotaro, Shiraishi Yuichi, Shiozawa Yusuke, Zenz Thorsten, Oakes Christopher C, Sawitzki Birgit, Schwarz Michaela, Bullinger Lars, le Coutre Philipp, Rose-Zerilli Matthew J J, Ogawa Seishi, Damm Frederik
Abstract excerpt
Cancer development is an evolutionary genomic process with parallels to Darwinian selection. It requires acquisition of multiple somatic mutations that collectively cause a malignant phenotype and continuous clonal evolution is often linked to tumor progression. Here, we show the clonal evolution structure in 15 myelofibrosis (MF) patients while receiving treatment with JAK inhibitors (mean follow-up 3.9 years)....
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