Article

Disrupting cellular memory to overcome drug resistance

2022-06-17

Abstract excerpt

Plasticity enables cells to change their gene expression state in the absence of a genetic change. At the single-cell level, these gene expression states can persist for different lengths of time which is a quantitative measurement referred to as gene expression memory. Because plasticity is not encoded by genetic changes, these cell states can be reversible, and therefore, are amenable to modulation by disrupting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3889fcd3-5b65-57db-ad42-93df75e6239d
DOI: 10.1101/2022.06.16.496161

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disrupting cellular memory to overcome drug resistanceDOI 10.1101/2022.06.16.496161Read

Identifying memory gene expression from single sample scRNA-seq data using power law signaturesSemantic proximity Read

Clonal dynamics shaped by diverse drug-tolerant persister states in melanoma resistanceSemantic proximity Read

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.Semantic proximity Read

Lineage Plasticity: The New Cancer Hallmark on the Block.Semantic proximity Read

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell lineSemantic proximity Read

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switchingSemantic proximity Read

Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanomaSemantic proximity Read

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanomaSemantic proximity Read

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancerSemantic proximity Read

Actionable biological programs to enhance EGFR-targeted therapy response unveiled by single-cell lineage tracing in clinically relevant lung cancer modelsSemantic proximity Read

Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistanceSemantic proximity Read

Dynamical hallmarks of cancer: Phenotypic switching in melanoma and epithelial-mesenchymal plasticity.Semantic proximity Read