Article

Spatiotemporal profiling defines persistence and resistance dynamics during targeted treatment of melanoma

2024-02-05

Abstract excerpt

Resistance of BRAF-mutant melanomas to targeted therapy arises from the ability of cells to enter a persister state, evade treatment with relative dormancy, and repopulate the tumor when reactivated. Using spatial transcriptomics in patient derived xenograft models, we capture clonal lineage evolution during treatment, finding the persister state to show increased oxidative phosphorylation, decreased proliferation...

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Literature Corpus work: 2e7f7e79-6012-5e3b-a9a7-9a927318f5df
DOI: 10.1101/2024.02.02.577085

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