Lineage Plasticity: The New Cancer Hallmark on the Block.

doi:10.1158/0008-5472.CAN-23-1067

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Article

Lineage Plasticity: The New Cancer Hallmark on the Block.

Cancer research - 16 Jan 2024

Mehta Arnav, Stanger Ben Z

Abstract excerpt

Plasticity refers to the ability of cells to adopt a spectrum of states or phenotypes. In cancer, it is a critical contributor to tumor initiation, progression, invasiveness, and therapy resistance, and it has recently been recognized as an emerging cancer hallmark. Plasticity can occur as a result of cell-intrinsic factors (e.g., genetic, transcriptional, or epigenetic fluctuations), or through cell-extrinsic...

Topics

Animals
Mice
Humans
Neoplasms
Tumor Microenvironment
Signal Transduction
Phenotype
Cell Plasticity

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Identifiers

PMID: 37963209
DOI: 10.1158/0008-5472.CAN-23-1067
PMCID: PMC10841583

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