Article

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma

2022-04-16

Abstract excerpt

Drug resistance and tumor relapse in melanoma patients is attributed to a combination of genetic and non-genetic mechanisms. Non-genetic mechanisms of drug resistance commonly involve reversible changes in the cell-state or phenotype, i.e., alterations in molecular profiles that can help cells escape being killed by targeted therapeutics. In melanoma, one of the most common mechanisms of non-genetic resistance is...

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Literature Corpus work: 7f3c33fa-31bb-5d17-836b-2565f815265a
DOI: 10.1101/2022.04.16.488373

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