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Article

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2017

Su Yapeng, Wei Wei, Robert Lidia, Xue Min, Tsoi Jennifer, Garcia-Diaz Angel, Homet Moreno Blanca, Kim Jungwoo, Ng Rachel H, Lee Jihoon W, Koya Richard C, Comin-Anduix Begonya, Graeber Thomas G, Ribas Antoni, Heath James R

Abstract excerpt

Continuous BRAF inhibition of BRAF mutant melanomas triggers a series of cell state changes that lead to therapy resistance and escape from immune control before establishing acquired resistance genetically. We used genome-wide transcriptomics and single-cell phenotyping to explore the response kinetics to BRAF inhibition for a panel of patient-derived BRAFV600 -mutant melanoma cell lines. A subset of plastic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29229836
DOI: 10.1073/pnas.1712064115
PMCID: PMC5748184

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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