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Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance

15 Jul 2020

Abstract excerpt

BACKGROUND: Tumors can evolve and adapt to therapeutic pressure by acquiring genetic and epigenetic alterations that may be transient or stable. A precise understanding of how such events contribute to intratumoral heterogeneity, dynamic subpopulations, and overall tumor fitness will require experimental approaches to prospectively label, track, and characterize resistant or otherwise adaptive populations at the...

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PMID: 32669109
DOI: 10.1186/s13059-020-02085-1

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