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Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line

11 May 2020

Abstract excerpt

Abstract The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon drugging. We integrate experiments and theory to determine the trajectories that single BRAFV600E mutant melanoma cancer cells take between drug-naive and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32393797
DOI: 10.1038/s41467-020-15956-9

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