Article
Dynamical hallmarks of cancer: Phenotypic switching in melanoma and epithelial-mesenchymal plasticity.
Seminars in cancer biology - 1 Nov 2023
Jain Paras, Pillai Maalavika, Duddu Atchuta Srinivas, Somarelli Jason A, Goyal Yogesh, Jolly Mohit Kumar
Abstract excerpt
Phenotypic plasticity was recently incorporated as a hallmark of cancer. This plasticity can manifest along many interconnected axes, such as stemness and differentiation, drug-sensitive and drug-resistant states, and between epithelial and mesenchymal cell-states. Despite growing acceptance for phenotypic plasticity as a hallmark of cancer, the dynamics of this process remains poorly understood. In particular,...
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