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Article

Antibody diversification: mutational mechanisms and oncogenesis.

Immunologic research - 1 Jan 2006

Frieder Darina, Larijani Mani, Tang Ephraim, Parsa Jahan-Yar, Basit Wajiha, Martin Alberto

Abstract excerpt

Antibody diversification processes play a major role in protecting humans from pathogens. Somatic hypermutation and gene conversion increase the affinity of pathogen-specific antibodies by changing the sequence within antibody variable genes, while the class switch recombination (CSR) process changes the antibody's effector function by replacing the constant region of the antibody gene with a different constant...

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Source

Identifiers

PMID: 17003511
DOI: 10.1385/IR:35:1:75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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