Article

Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation

2021-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Germinal centers (GC) are microstructures where B cells that have been activated by antigen can improve the affinity of their B cell receptors and differentiate into memory B cells (MBCs) or antibody secreting plasma cells. Activation Induced Deaminase (AID) initiates antibody diversification in GCs by somatic hypermutation and class switch recombination. Here we have addressed the role of AID i...

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Literature Corpus work: a3ce8290-e2ec-5b7c-bce7-6d33d7dc0381
DOI: 10.1101/2021.06.03.446763

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