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Article

Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans.

eLife - 9 Dec 2019

Lee Teresa Wei-Sy, David Heidi Shira, Engstrom Amanda Kathryn, Carpenter Brandon Scott, Katz David John

Abstract excerpt

In Caenorhabditis elegans, mutations in WDR-5 and other components of the COMPASS H3K4 methyltransferase complex extend lifespan and enable its inheritance. Here, we show that wdr-5 mutant longevity is itself a transgenerational trait that corresponds with a global enrichment of the heterochromatin factor H3K9me2 over twenty generations. In addition, we find that the transgenerational aspects of wdr-5 mutant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31815663
DOI: 10.7554/eLife.48498
PMCID: PMC7299346

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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