Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons.

doi:10.1073/pnas.2513137122

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Article

Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2025

Rodriguez Juan D, Reeves Monica N, Chavez Sindy R, Wang Hsiao-Lin V, Chavez Jaely Z, Rastogi Rhea, Sun Liyang I, Roberson Mackenzie S, Preston Elicia A, Massenburg Zaynab, Cruz Kiani N, Chadha Madhav S, Hill Emily J, Soares Miguel L, Corces Victor G, Carpenter Brandon S, Schmeichel Karen L, Murray John I, Katz David J

Abstract excerpt

How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown. To address this question, we took advantage of the invariant embryonic lineage and adult nervous system in Caenorhabditis elegans to investigate a double mutant between spr-5/Lsd1/Kdm1a (H3K4me1/2 demethylase) and met-2/Setdb1/Kmt1e (H3K9 methyltransferase). We demonstrate that spr-5; met-2 double mutant worms have a severe...

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PMID: 40991443
DOI: 10.1073/pnas.2513137122
PMCID: PMC12501177

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