Article

H3K9me2 protects lifespan against the transgenerational burden of germline transcription in <i>C. elegans</i>

2019-09-25

Abstract excerpt

<h4>ABSTRACT</h4> During active transcription, the COMPASS complex methylates histone H3 at lysine 4 (H3K4me). In Caenorhabditis elegans , mutations in COMPASS subunits, including WDR-5, extend lifespan and enable the inheritance of increased lifespan in wild-type descendants. Here we show that the increased lifespan of wdr-5 mutants is itself a transgenerational trait that manifests after eighteen generations...

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Literature Corpus work: f8151356-7d26-5b5a-b0cb-088999117ae4
DOI: 10.1101/782136

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