Article

Similar deamination activity but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells

2023-04-01

Abstract excerpt

APOBEC3 (A3) enzymes deaminate cytosine to uracil in viral single-stranded DNA as a mutagenic barrier for some viruses. A3-induced deaminations can also occur in human genomes resulting in an endogenous source of somatic mutations in multiple cancers. However, the roles of each A3 are unclear since few studies have assessed these enzymes in parallel. Thus, we developed stable cell lines expressing A3A, A3B, or A3H...

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Literature Corpus work: 3775ac89-e833-5264-9187-3257b7cf8777
DOI: 10.1101/2023.03.29.534844

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