Article
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
eLife - 16 Apr 2013
Taylor Benjamin Jm, Nik-Zainal Serena, Wu Yee Ling, Stebbings Lucy A, Raine Keiran, Campbell Peter J, Rada Cristina, Stratton Michael R, Neuberger Michael S
Abstract excerpt
Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with sites of DNA rearrangement. We show kataegis can result from AID/APOBEC-catalysed cytidine deamination in the vicinity of DNA breaks, likely through action on...
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