Article
The APOBEC3A deaminase drives episodic mutagenesis in cancer cells
2021-02-14
Abstract excerpt
<h4>ABSTRACT</h4> The APOBEC3 family of cytidine deaminases is widely speculated to be a major source of somatic mutations in cancer 1–3 . However, causal links between APOBEC3 enzymes and mutations in human cancer cells have not been established. The identity of the APOBEC3 paralog(s) that may act as prime drivers of mutagenesis and the mechanisms underlying different APOBEC3-associated mutational signatures ar...
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Identifiers and source
- Literature Corpus work
- 42aecd65-df54-5ac8-8500-3efa041306b7
- DOI
- 10.1101/2021.02.14.431145