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Mechanisms of APOBEC3 mutagenesis in human cancer cells

20 Jul 2022

Abstract excerpt

Abstract The APOBEC3 family of cytosine deaminases has been implicated in some of the most prevalent mutational signatures in cancer 1–3 . However, a causal link between endogenous APOBEC3 enzymes and mutational signatures in human cancer genomes has not been established, leaving the mechanisms of APOBEC3 mutagenesis poorly understood. Here, to investigate the mechanisms of APOBEC3 mutagenesis, we deleted...

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PMID: 35859169
DOI: 10.1038/s41586-022-04972-y

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