Article
APOBEC3A is a prominent cytidine deaminase in breast cancer.
PLoS genetics - 1 Dec 2019
Cortez Luis M, Brown Amber L, Dennis Madeline A, Collins Christopher D, Brown Alexander J, Mitchell Debra, Mertz Tony M, Roberts Steven A
Abstract excerpt
APOBEC cytidine deaminases are the second-most prominent source of mutagenesis in sequenced tumors. Previous studies have proposed that APOBEC3B (A3B) is the major source of mutagenesis in breast cancer (BRCA). We show that APOBEC3A (A3A) is the only APOBEC whose expression correlates with APOBEC-induced mutation load and that A3A expression is responsible for cytidine deamination in multiple BRCA cell lines....
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