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Article

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.

PloS one - 1 Jan 2016

Akre Monica K, Starrett Gabriel J, Quist Jelmar S, Temiz Nuri A, Carpenter Michael A, Tutt Andrew N J, Grigoriadis Anita, Harris Reuben S

Abstract excerpt

Molecular, cellular, and clinical studies have combined to demonstrate a contribution from the DNA cytosine deaminase APOBEC3B (A3B) to the overall mutation load in breast, head/neck, lung, bladder, cervical, ovarian, and other cancer types. However, the complete landscape of mutations attributable to this enzyme has yet to be determined in a controlled human cell system. We report a conditional and isogenic...

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Identifiers

PMID: 27163364
DOI: 10.1371/journal.pone.0155391
PMCID: PMC4862684

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MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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