Article
APOBEC3B is an enzymatic source of mutation in breast cancer.
Nature - 21 Feb 2013
Burns Michael B, Lackey Lela, Carpenter Michael A, Rathore Anurag, Land Allison M, Leonard Brandon, Refsland Eric W, Kotandeniya Delshanee, Tretyakova Natalia, Nikas Jason B, Yee Douglas, Temiz Nuri A, Donohue Duncan E, McDougle Rebecca M, Brown William L, Law Emily K, Harris Reuben S
Abstract excerpt
Several mutations are required for cancer development, and genome sequencing has revealed that many cancers, including breast cancer, have somatic mutation spectra dominated by C-to-T transitions. Most of these mutations occur at hydrolytically disfavoured non-methylated cytosines throughout the genome, and are sometimes clustered. Here we show that the DNA cytosine deaminase APOBEC3B is a probable source of...
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