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Article

Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.

Breast cancer research : BCR - 21 Jan 2015

Harris Reuben S

Abstract excerpt

Cancer genomic DNA sequences enable identification of all mutations and suggest targets for precision medicine. The identities and patterns of the mutations themselves also provide critical information for deducing the originating DNA damaging agents, causal molecular mechanisms, and thus additional therapeutic targets. A classic example is ultraviolet light, which crosslinks adjacent pyrimidines and leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25848704
DOI: 10.1186/s13058-014-0498-3
PMCID: PMC4303225

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