Article

Cannabinoid CB <sub>2</sub> receptor activation drives glucose uptake, shifting T cell metabolism

2026-07-10

Abstract excerpt

Cannabinoid receptor 2 (CB 2 R) is highly expressed on immune cells, but its role in T cell metabolism remains unclear. Here, we show that CB 2 R activation rapidly increases glucose uptake in human Jurkat T cells and drives a broader metabolic reprogramming away from glycolysis toward oxidative metabolism and the pentose phosphate pathway. Pharmacological CB 2 R activation increased mitochondrial mass, spare r...

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Identifiers and source

Literature Corpus work: 377364e1-a6cf-5385-aa7d-50a26cde66fe
DOI: 10.64898/2026.07.07.736985

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