Article

Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes

2025-11-26

Abstract excerpt

<h4>Introduction: </h4> Brown adipocytes consume higher amounts of metabolic substrates and regulators including thiamine during adrenergic stimulation supporting heat generation. Our previous findings showed that fedratinib, a potent inhibitor of thiamine transporter (ThTr) 2 and Janus kinase 2 (JAK2), reduced thermogenic activity; however, the underlying molecular mechanisms remain elusive. <h4>Methods:</h4> Pri...

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Literature Corpus work: 0ab5ea18-73c8-5562-ad97-eee6c208ecb7
DOI: 10.1101/2025.11.24.690155

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