Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection

Abstract excerpt

The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis ( Mtb ) and M. bovis BCG infections rewire metabolic circuits and alter effector functions in lung CD8 + T cells. As Mtb infection progresses, mitochondrial metabolism deteriorates in CD8 + T cells, resulting in an increased dependency on glycolysis that...

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