Article

Multi-Omic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines

2020-06-04

Abstract excerpt

The non-psychoactive cannabinoid, cannabidiol (CBD), is FDA-approved for treatment of two drug-resistant epileptic disorders, and is seeing increased use among the general public, yet the mechanisms that underlie its therapeutic effects and side-effect profiles remain unclear. Here, we report a systems-level analysis of CBD action in human cell lines using temporal multi-omic profiling. FRET-based biosensor screen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48c3a08f-6c28-5232-aa27-be72b4f326bf
DOI: 10.1101/2020.06.03.130864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-Omic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell LinesDOI 10.1101/2020.06.03.130864Read

Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.Semantic proximity Read

Cannabidiol and Alzheimer disease: A Comprehensive Review and In Silico Insights into Molecular InteractionsSemantic proximity Read

Comparative analysis of 105 datasets across species and tissues reveals higher variability in transcriptomic responses to THC than CBDSemantic proximity Read

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.Semantic proximity Read

The expression of cannabinoid-related genes in multiple disease cell linesSemantic proximity Read

Proteomic and metabolomic analyses reveal the antibacterial mechanism of Cannabidiol against gram-positive bacteriaSemantic proximity Read

Cannabidiol administration reduces the expression of genes involved in mitochondrial electron transport chain and ribosome biogenesis in mice CA1 neuronsSemantic proximity Read

Cholesterol and matrisome pathways dysregulated in astrocytes and microgliaSemantic proximity Read

A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization.Semantic proximity Read

A Facile LC-MS Method for Profiling Cholesterol and Cholesteryl Esters in Mammalian Cells and TissuesSemantic proximity Read

Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in DiseaseSemantic proximity Read

Cannabidiol potentiates p53-driven autophagic cell death in non-small cell lung cancer following DNA damage: a novel synergistic approach beyond canonical pathwaysSemantic proximity Read