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Article

The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

Cell metabolism - 6 Jun 2012

Haschemi Arvand, Kosma Paul, Gille Lars, Evans Charles R, Burant Charles F, Starkl Philipp, Knapp Bernhard, Haas Robert, Schmid Johannes A, Jandl Christoph, Amir Shahzada, Lubec Gert, Park Jaehong, Esterbauer Harald, Bilban Martin, Brizuela Leonardo, Pospisilik J Andrew, Otterbein Leo E, Wagner Oswald

Abstract excerpt

Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations necessary to mount such dramatic phenotypic shifts. Screening for novel regulators of macrophage activation, we found no...

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Identifiers

PMID: 22682222
DOI: 10.1016/j.cmet.2012.04.023
PMCID: PMC3370649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22682222-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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